Biografia
Il dott. Andrea Alexandre si è laureato in medicina e chirurgia presso l'Università Campus Bio-Medico di Roma, con il massimo dei voti e lode.
Durante gli anni universitari ha frequentato il dipartimento di neurochirurgia del Queen Mary University Hospital di Londra come "medical elective student" e successivamente quello dell'Imperial College University - West London Neuroscience Centre, sempre a Londra, con il Prof. F.Afshar.
Ha proseguito gli studi ottenendo la specializzazione in Radiologia, sempre con il massimo dei voti e lode, presso l'Università Cattolica del Sacro Cuore di Roma, con il prof. Cesare Colosimo.
Durante la specializzazione frequenta l'Unità Operativa Complessa di Neuroradiologia di Cesena per un periodo di sei mesi.
Ha terminato la sua formazione a Parigi, dove ha svolto fellowship in neuroradiologia interventistica, presso il centro Neuri (Brain Vascular Center) negli ospedali Beaujon e Bicêtre, per un periodo di due anni, specializzandosi nel trattamento minimamente invasivo delle malformazioni vascolari cerebrali, con il Prof J.Moret e L.Spelle.
Allo stesso tempo, si è specializzato nel trattamento minimamente invasivo delle patologie degenerative della colonna vertebrale, presso il centro EU.N.I. (European Neurosurgical Institute) di Treviso.
Attualmente lavora come Dirigente Medico nell'Unità Operativa Complessa di Radiologia e Neuroradiologia della Fondazione Policlinico Universitario A.Gemelli IRCCS di Roma.
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Principali ambiti di ricerca del dott. Alexandre sono le tecniche diagnostiche ed interventistiche nelle patologie cerebro-vascolari e rachidee.
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Le tecniche diagnostiche (imaging in neuroradiologia) comprendono la Risonanza Magnetica, la TC, l'angiografia digitale a sottrazione (DSA) e la radiologia tradizionale.
Le tecniche interventistiche includono:
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1) trattamenti mini-invasivi per aneurismi, fistole e malformazioni vascolari cerebrali, effettuati per via endovascolare;
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2) procedure mini-invasive per le patologie degenerative del rachide, quali ernie del disco, degenerazione discale e stenosi del canale spinale, effettuati per via percutanea, senza incisioni chirurgiche.
Istruzione & Formazione
2015-tempo presente
Dirigente Medico UOC Radiologia e Neuroradiologia, Fondazione Policlinico Universitario A.Gemelli IRCCS, Roma
2014-2015
Fellowship Neuri Brain Vascular Center, Parigi
2009-2014
Specializzazione in Radiologia Università Cattolica del Sacro Cuore, Roma
2008
Laurea in Medicina e Chirurgia, Università Campus Bio-Medico di Roma
Pubblicazioni Scientifiche
- Interv Neuroradiol 2019, Pre-operative direct puncture embolization of head and neck hypervascular tumors using SQUID 12. -
OBJECTIVE: The authors have evaluated their experience in pre-operative direct puncture embolization of hypervascular tumors of the head and neck using SQUID 12, an embolic liquid agent.
METHODS:
Between July 2016 and March 2019, the authors retrospectively reviewed clinical, embolization and surgical data of 11 consecutive patients with 12 hypervascular head and neck tumors who had undergone pre-operative embolization using SQUID 12. Percutaneous embolizations were performed by inserting a 19-22 Gauge needle directly into the tumor under ultrasound, fluoroscopic and/or endoscopic guidance. The hub of the needle was connected to a 15-cm DMSO-compatible extension tube, and the SQUID 12 was injected.
RESULTS:
Total or near-total devascularization was achieved in 11 over 12 cases. Complete en-bloc tumor removal by surgery was achieved in all cases. Only one patient required blood transfusion. No major periprocedural adverse events were recorded.
CONCLUSIONS:
Direct puncture embolization of hypervascular tumors of the head and neck using SQUID 12 seems to be safe and effective. It may offer almost complete devascularization due to homogenous, deep penetration in the tumor, with optimal visibility of the agent throughout the percutaneous procedure. It may reduce intraoperative blood loss and the need for transfusion, thus facilitating complete surgical resection.
- J Neuroradiol 2019, The low-profile Neuroform Atlas stent in the treatment of wide-necked intracranial aneurysms - immediate and midterm results: An Italian multicenter registry. -
BACKGROUND AND PURPOSE: Wide-necked brain aneurysms therapy remains a challenge for neurointerventionalists, mainly for the high recurrence rate. Low-profile stents make feasible the treatment of these aneurysms. In our multicenter series we analyzed clinical and angiographic results of Neuroform Atlas stent-assisted coiling.
MATERIALS AND METHODS:
From January 2016 to March 2017, 113 wide-necked aneurysms were discovered with CTA, MRA and DSA. The Atlas stent-assisted coiling procedures were performed under general anesthesia with sequential or jailing techniques. Six months follow-up DSA was performed to assess the recurrence rate through the modified Raymond-Roy occlusion scale (RROC). Moreover, patients were evaluated clinically to analyse the degree of disability according to the mRS. MRI was performed at 12 months evaluating both the cerebral tissue and the vessels.
RESULTS:
In all the procedures it was feasible to navigate the Neuroform Atlas to the goal vessel and deploy the stent across the aneurysmal neck. Intra-procedural complications account for the 6.2% (7/113). The immediate occlusion rate was RROC 1 in 88%, 2 in 9% and 3 in 3% of cases. The 6 months clinical data showed mRS Score 0-1 in 96.5% of patients; 3 patients died of complications related to SAH. The 12 months follow-up showed RROC of 1 in 82%, 2 in 13% and 3 in 5% of cases. No aneurysm has been retreated.
CONCLUSIONS:
In our multicenter experience the Neuroform Atlas stent assisted-coiling has shown to be a safe and effective technique for the treatment of wide-necked intracranial aneurysms with encouraging clinical and angiographic results.
Riconoscimenti
- 2019 -
Top Oral Paper Award al Congresso Mondiale di Neuroradiologia Interventistica (WFITN 2019, Napoli)
- 2012 -
Poster Didattico, Premiato con Certificato di Merito. 45^ Congresso SIRM, Torino 1-5 giugno 2012.
- 2010 -
Poster Didattico, Premiato con Certificato di Merito. 44^ Congresso SIRM, Verona 10-15 giugno 2010.